Principales publications


Tau Monoclonal Antibody Generation based on Humanized Yeast Models: Impact on Tau Oligomerization and Diagnostics.

Rosseels J, Van den Brande J, Violet M, Jacobs D, Grognet P, Lopez J, Huvent I, Caldara M, Swinnen E, Papegaey A, Caillierez R, Buée-Scherrer V, Engelborghs S, Lippens G, Colin M, Buée L, Galas MC, Vanmechelen E, Winderickx J.
J Biol Chem. 2014 Dec 24. pii: jbc.M114.627919. [Epub ahead of print]

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.
Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Mariciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D’Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D.
Mol Psychiatry. 2014 Dec 2. doi: 10.1038/mp.2014.151. [Epub ahead of print]

Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.
Ahmed T, Blum D, Burnouf S, Demeyer D, Buée-Scherrer V, D’Hooge R, Buée L, Balschun D.
Neurobiol Aging. 2014 Sep 28. pii: S0197-4580(14)00620-4. doi: 10.1016/j.neurobiolaging.2014.09.015. [Epub ahead of print]

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice.
Martel G, Simon A, Nocera S, Kalainathan S, Pidoux L, Blum D, Leclère-Turbant S, Diaz J, Geny D, Moyse E, Videau C, Buée L, Epelbaum J, Viollet C.
Neurobiol Aging. 2014 Oct 31. pii: S0197-4580(14)00693-9. doi: 10.1016/j.neurobiolaging.2014.10.033. [Epub ahead of print]

Animal models of tauopathies and their implications for research/translation into the clinic.
Dujardin S, Colin M, Buée L.
Neuropathol Appl Neurobiol. 2014 Nov 26. doi: 10.1111/nan.12200. [Epub ahead of print]

Rapamycin Ester Analog CCI-779/Temsirolimus Alleviates Tau Pathology and Improves Motor Deficit in Mutant Tau Transgenic Mice.
Frederick C, Ando K, Leroy K, Héraud C, Suain V, Buée L, Brion JP.
J Alzheimers Dis. 2014 Nov 14. [Epub ahead of print]

EVpedia: a community web portal for extracellular vesicles research.
Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borràs FE, Buée L, Buzás EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekström K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-‘t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jørgensen M, Kim KP, Kim YK, Kislinger T, Lässer C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lötvall J, Marcilla A, Mathivanan S, Möller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stępień E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yáñez-Mó M, Youn H, Zeidler R, Gho YS.
Bioinformatics. 2014 Nov 10. pii: btu741. [Epub ahead of print]

Plasma β-amyloid and MRI markers of cerebral small vessel disease: Three-City Dijon study.
Kaffashian S, Tzourio C, Soumaré A, Dufouil C, Zhu Y, Crivello F, Maillard P, Schraen-Maschke S, Mazoyer B, Buée L, Debette S.
Neurology. 2014 Nov 25;83(22):2038-45. doi: 10.1212/WNL.0000000000001038. Epub 2014 Oct 29.

Immunodetection of Tau microtubule-associated protein in human sperm and testis.
Sigala J, Jumeau F, Caillet-Boudin ML, Sergeant N, Ballot C, Rigot JM, Marcelli F, Tardivel M, Buée L, Mitchell V.
Asian J Androl. 2014 Nov-Dec;16(6):927-8. doi: 10.4103/1008-682X.136446.

Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF.
Hum Mol Genet. 2015 Jan 1;24(1):76-85. doi: 10.1093/hmg/ddu421. Epub 2014 Aug 20.

TMEM240 mutations cause spinocerebellar ataxia 21 with mental retardation and severe cognitive impairment.
Delplanque J, Devos D, Huin V, Genet A, Sand O, Moreau C, Goizet C, Charles P, Anheim M, Monin ML, Buée L, Destée A, Grolez G, Delmaire C, Dujardin K, Dellacherie D, Brice A, Stevanin G, Strubi-Vuillaume I, Dürr A, Sablonnière B.
Brain. 2014 Oct;137(Pt 10):2657-63. doi: 10.1093/brain/awu202. Epub 2014 Jul 28.

Plasma β-amyloid 40 levels are positively associated with mortality risks in the elderly.
Gabelle A, Schraen S, Gutierrez LA, Pays C, Rouaud O, Buée L, Touchon J, Helmer C, Lambert JC, Berr C.
Alzheimers Dement. 2014 Jul 8. pii: S1552-5260(14)00643-8. doi: 10.1016/j.jalz.2014.04.515.

PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer’s disease in the hippocampus and spatial memory impairments.
Chaalal A, Poirier R, Blum D, Gillet B, Le Blanc P, Basquin M, Buée L, Laroche S, Enderlin V.
Hippocampus. 2014 Nov;24(11):1381-93. doi: 10.1002/hipo.22319. Epub 2014 Jul 22.

Ectosomes: a new mechanism for non-exosomal secretion of tau protein.
Dujardin S, Bégard S, Caillierez R, Lachaud C, Delattre L, Carrier S, Loyens A, Galas MC, Bousset L, Melki R, Aurégan G, Hantraye P, Brouillet E, Buée L, Colin M.
PLoS One. 2014 Jun 27;9(6):e100760. doi: 10.1371/journal.pone.0100760. eCollection 2014.

Recovery of brain biomarkers following peroxisome proliferator-activated receptor agonist neuroprotective treatment before ischemic stroke.
Gelé P, Vingtdeux V, Potey C, Drobecq H, Ghestem A, Melnyk P, Buée L, Sergeant N, Bordet R.
Proteome Sci. 2014 May 6;12:24. doi: 10.1186/1477-5956-12-24. eCollection 2014.

Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion.
Ahmed T, Van der Jeugd A, Blum D, Galas MC, D’Hooge R, Buee L, Balschun D.
Neurobiol Aging. 2014 Nov;35(11):2474-8. doi: 10.1016/j.neurobiolaging.2014.05.005.

Beneficial effects of caffeine in a transgenic model of Alzheimer’s disease-like tau pathology.
Laurent C, Eddarkaoui S, Derisbourg M, Leboucher A, Demeyer D, Carrier S, Schneider M, Hamdane M, Müller CE, Buée L, Blum D.
Neurobiol Aging. 2014 Sep;35(9):2079-90. doi: 10.1016/j.neurobiolaging.2014.03.027.

Consensus brain-derived protein, extraction protocol for the study of human and murine brain proteome using both 2D-DIGE and mini 2DE immunoblotting.
Fernandez-Gomez FJ, Jumeau F, Derisbourg M, Burnouf S, Tran H, Eddarkaoui S, Obriot H, Dutoit-Lefevre V, Deramecourt V, Mitchell V, Lefranc D, Hamdane M, Blum D, Buée L, Buée-Scherrer V, Sergeant N.
J Vis Exp. 2014 Apr 10;(86). doi: 10.3791/51339.

Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis.
Charton J, Gauriot M, Guo Q, Hennuyer N, Marechal X, Dumont J, Hamdane M, Pottiez V, Landry V, Sperandio O, Flipo M, Buee L, Staels B, Leroux F, Tang WJ, Deprez B, Deprez-Poulain R.
Eur J Med Chem. 2014 May 22;79:184-93. doi: 10.1016/j.ejmech.2014.04.009.

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions.
Violet M, Delattre L, Tardivel M, Sultan A, Chauderlier A, Caillierez R, Talahari S, Nesslany F, Lefebvre B, Bonnefoy E, Buée L, Galas MC.
Front Cell Neurosci. 2014 Mar 18;8:84. doi: 10.3389/fncel.2014.00084. eCollection 2014.

From epidemiology to pathophysiology: what about caffeine in Alzheimer’s disease?
Flaten V, Laurent C, Coelho JE, Sandau U, Batalha VL, Burnouf S, Hamdane M, Humez S, Boison D, Lopes LV, Buée L, Blum D.
Biochem Soc Trans. 2014 Apr;42(2):587-92. doi: 10.1042/BST20130229.

A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.
Chouraki V, De Bruijn RF, Chapuis J, Bis JC, Reitz C, Schraen S, Ibrahim-Verbaas CA, Grenier-Boley B, Delay C, Rogers R, Demiautte F, Mounier A, Fitzpatrick AL; Alzheimer’s Disease Neuroimaging Initiative, Berr C, Dartigues JF, Uitterlinden AG, Hofman A, Breteler M, Becker JT, Lathrop M, Schupf N, Alpérovitch A, Mayeux R, van Duijn CM, Buée L, Amouyel P, Lopez OL, Ikram MA, Tzourio C, Lambert JC.
Mol Psychiatry. 2014 Dec;19(12):1326-35. doi: 10.1038/mp.2013.185.

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.
Dujardin S, Lécolle K, Caillierez R, Bégard S, Zommer N, Lachaud C, Carrier S, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Colin M, Buée L.
Acta Neuropathol Commun. 2014 Jan 30;2:14. doi: 10.1186/2051-5960-2-14.

Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2.
Carpentier C, Ghanem D, Fernandez-Gomez FJ, Jumeau F, Philippe JV, Freyermuth F, Labudeck A, Eddarkaoui S, Dhaenens CM, Holt I, Behm-Ansmant I, Marmier-Gourrier N, Branlant C, Charlet-Berguerand N, Marie J, Schraen-Maschke S, Buée L, Sergeant N, Caillet-Boudin ML.
Biochim Biophys Acta. 2014 Apr;1842(4):654-64. doi: 10.1016/j.bbadis.2014.01.004.

Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy.
Caillet-Boudin ML, Fernandez-Gomez FJ, Tran H, Dhaenens CM, Buee L, Sergeant N.
Front Mol Neurosci. 2014 Jan 9;6:57. doi: 10.3389/fnmol.2013.00057. Review.

Juvenile frontotemporal dementia with parkinsonism associated with tau mutation G389R.
Chaunu MP, Deramecourt V, Buée-Scherrer V, Le Ber I, Brice A, Ehrle N, El Hachimi K, Pluot M, Maurage CA, Bakchine S, Buée L.
J Alzheimers Dis. 2013;37(4):769-76. doi: 10.3233/JAD-130413.

Progressive age-related cognitive decline in tau mice.
Van der Jeugd A, Vermaercke B, Derisbourg M, Lo AC, Hamdane M, Blum D, Buée L, D’Hooge R.
J Alzheimers Dis. 2013;37(4):777-88. doi: 10.3233/JAD-130110.

Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer’s disease.
Lo AC, Iscru E, Blum D, Tesseur I, Callaerts-Vegh Z, Buée L, De Strooper B, Balschun D, D’Hooge R.
J Alzheimers Dis. 2013;37(1):109-25. doi: 10.3233/JAD-122296.

Association between caffeine intake and age at onset in Huntington’s disease.
Simonin C, Duru C, Salleron J, Hincker P, Charles P, Delval A, Youssov K, Burnouf S, Azulay JP, Verny C, Scherer C, Tranchant C, Goizet C, Debruxelles S, Defebvre L, Sablonnière B, Romon-Rousseaux M, Buée L, Destée A, Godefroy O, Dürr A, Landwehrmeyer B; REGISTRY Study of the European Huntington’s Disease Network, Bachoud-Levi AC, Richard F, Blum D, Krystkowiak P; Huntington French Speaking Network.
Neurobiol Dis. 2013 Oct;58:179-82. doi: 10.1016/j.nbd.2013.05.013.

Alzheimer’s disease risk, obesity and tau: is insulin resistance guilty?
Blum D, Buée L.
Expert Rev Neurother. 2013 May;13(5):461-3. doi: 10.1586/ern.13.35.

Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M.
Mol Ther. 2013 Jul;21(7):1358-68. doi: 10.1038/mt.2013.66.

Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.
Hernández-Hernández O, Guiraud-Dogan C, Sicot G, Huguet A, Luilier S, Steidl E, Saenger S, Marciniak E, Obriot H, Chevarin C, Nicole A, Revillod L, Charizanis K, Lee KY, Suzuki Y, Kimura T, Matsuura T, Cisneros B, Swanson MS, Trovero F, Buisson B, Bizot JC, Hamon M, Humez S, Bassez G, Metzger F, Buée L, Munnich A, Sergeant N, Gourdon G, Gomes-Pereira M.
Brain. 2013 Mar;136(Pt 3):957-70. doi: 10.1093/brain/aws367.

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.
Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV, Geller F, Sottejeau Y, Harold D, Dourlen P, Grenier-Boley B, Kamatani Y, Delepine B, Demiautte F, Zelenika D, Zommer N, Hamdane M, Bellenguez C, Dartigues JF, Hauw JJ, Letronne F, Ayral AM, Sleegers K, Schellens A, Broeck LV, Engelborghs S, De Deyn PP, Vandenberghe R, O’Donovan M, Owen M, Epelbaum J, Mercken M, Karran E, Bantscheff M, Drewes G, Joberty G, Campion D, Octave JN, Berr C, Lathrop M, Callaerts P, Mann D, Williams J, Buée L, Dewachter I, Van Broeckhoven C, Amouyel P, Moechars D, Dermaut B, Lambert JC; GERAD consortium.
Mol Psychiatry. 2013 Nov;18(11):1225-34. doi: 10.1038/mp.2013.1.

Synaptic protein dysregulation in myotonic dystrophy type 1: Disease neuropathogenesis beyond missplicing.
Hernández-Hernández O, Sicot G, Dinca DM, Huguet A, Nicole A, Buée L, Munnich A, Sergeant N, Gourdon G, Gomes-Pereira M.
Rare Dis. 2013 Jun 26;1:e25553. doi: 10.4161/rdis.25553. eCollection 2013.

Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Leboucher A, Laurent C, Fernandez-Gomez FJ, Burnouf S, Troquier L, Eddarkaoui S, Demeyer D, Caillierez R, Zommer N, Vallez E, Bantubungi K, Breton C, Pigny P, Buée-Scherrer V, Staels B, Hamdane M, Tailleux A, Buée L, Blum D.
Diabetes. 2013 May;62(5):1681-8. doi: 10.2337/db12-0866.

Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia.
Van der Jeugd A, Blum D, Raison S, Eddarkaoui S, Buée L, D’Hooge R.
Behav Brain Res. 2013 Apr 1;242:34-9. doi: 10.1016/j.bbr.2012.12.008.

Impact of the 2008-2012 French Alzheimer Plan on the use of cerebrospinal fluid biomarkers in research memory center: the PLM Study.
Gabelle A, Dumurgier J, Vercruysse O, Paquet C, Bombois S, Laplanche JL, Peoc’h K, Schraen S, Buée L, Pasquier F, Hugon J, Touchon J, Lehmann S.
J Alzheimers Dis. 2013;34(1):297-305. doi: 10.3233/JAD-121549.

MBNL1 gene variants as modifiers of disease severity in myotonic dystrophy type 1.
Huin V, Vasseur F, Schraen-Maschke S, Dhaenens CM, Devos P, Dupont K, Sergeant N, Buée L, Lacour A, Hofmann-Radvanyi H, Sablonnière B.
J Neurol. 2013 Apr;260(4):998-1003. doi: 10.1007/s00415-012-6740-y.

NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.
Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, Fernandez-Gomez FJ, Troquier L, Eddarkaoui S, Grosjean ME, Demeyer D, Muhr-Tailleux A, Buisson A, Sergeant N, Hamdane M, Humez S, Popoli P, Buée L, Blum D.
Aging Cell. 2013 Feb;12(1):11-23. doi: 10.1111/acel.12018.

A new decision tree combining Abeta 1-42 and p-Tau levels in Alzheimer’s diagnosis.
Bombois S, Duhamel A, Salleron J, Deramecourt V, Mackowiak MA, Deken V, Sergeant N, Pasquier F, Buée L, Sablonniére B, Schraen-Maschke S.
Curr Alzheimer Res. 2013 May 1;10(4):357-64.

Plasma amyloid-β levels and prognosis in incident dementia cases of the 3-City Study.
Gabelle A, Richard F, Gutierrez LA, Schraen S, Delva F, Rouaud O, Buée L, Dartigues JF, Touchon J, Lambert JC, Berr C.
J Alzheimers Dis. 2013;33(2):381-91. doi: 10.3233/JAD-2012-121147.

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
Ando K, Dourlen P, Sambo AV, Bretteville A, Bélarbi K, Vingtdeux V, Eddarkaoui S, Drobecq H, Ghestem A, Bégard S, Demey-Thomas E, Melnyk P, Smet C, Lippens G, Maurage CA, Caillet-Boudin ML, Verdier Y, Vinh J, Landrieu I, Galas MC, Blum D, Hamdane M, Sergeant N, Buée L.
Neurobiol Aging. 2013 Mar;34(3):757-69. doi: 10.1016/j.neurobiolaging.2012.08.004.

Sstr2A: a relevant target for the delivery of genes into human glioblastoma cells using fiber-modified adenoviral vectors.
Lécolle K, Bégard S, Caillierez R, Demeyer D, Grellier E, Loyens A, Csaba Z, Beauvillain JC, D’Halluin JC, Baroncini M, Lejeune JP, Sharif A, Prévot V, Dournaud P, Buée L, Colin M.
Gene Ther. 2013 Mar;20(3):283-97. doi: 10.1038/gt.2012.39.

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer’s disease.
Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, Alvarez V, Sims R, Gerrish A, Chapman J, Deniz-Naranjo C, Solfrizzi V, Sorbi S, Arosio B, Spalletta G, Siciliano G, Epelbaum J, Hannequin D, Dartigues JF, Tzourio C, Berr C, Schrijvers EM, Rogers R, Tosto G, Pasquier F, Bettens K, Van Cauwenberghe C, Fratiglioni L, Graff C, Delepine M, Ferri R, Reynolds CA, Lannfelt L, Ingelsson M, Prince JA, Chillotti C, Pilotto A, Seripa D, Boland A, Mancuso M, Bossù P, Annoni G, Nacmias B, Bosco P, Panza F, Sanchez-Garcia F, Del Zompo M, Coto E, Owen M, O’Donovan M, Valdivieso F, Caffarra P, Scarpini E, Combarros O, Buée L, Campion D, Soininen H, Breteler M, Riemenschneider M, Van Broeckhoven C, Alpérovitch A, Lathrop M, Trégouët DA, Williams J, Amouyel P.
Mol Psychiatry. 2013 Apr;18(4):461-70. doi: 10.1038/mp.2012.14.