Equipe VP

A principal goal in brain development is to produce the necessary neural architecture for integration of information from the external environment with internal cues that reflect important aspects of an animal’s physiological state. This integration allows the elaboration of adaptive behavioral and physiological responses that are essential for an individual’s survival, as well as for propagation of the species. It is well established that many circulating hormones represent important environmental signals that act directly on the central nervous system (CNS) to regulate its development and activity. Our laboratory studies how peripheral hormones (estrogen, AMH, leptin, ghreline, insulin…) impact hypothalamic development and function as well as aims at determining the importance of non-neuronal cells (tanycytes, astrocytes and endothelial cells) in this dialogue, which is set between the periphery and the central nervous system. It also evaluates how pathologies (such as obesity, diabetes, polycystic ovary syndrome) may affect these neurobiological events and, conversely, how impairment of brain communication with the periphery renders the organism prone to develop pathologies (obesity, diabetes, precocious and/or delayed puberty and infertility).