Principales publications

Gronnier C, Bruyère E, Piessen G, Briez E, Bot J, Buob D, Leteurtre E, Van Seuningen I, Mariette C.
Surgically-induced chronic reflux in rats: an accurate model for studying esophageal carcinogenesis?
Surgery, sous presse. IF : 3,103

Skrypek N, Duchene B, Hebbar M, Leteurtre E, Van Seuningen I, Jonckheere N.
The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the concentrative nucleoside transporter family.
Oncogene, 2013 Mar 28;32(13):1714-1723. IF : 6,37.

Perrais M, Rousseaux C, Ducourouble MP, Courcol R, Vincent P, Jonckheere N, Van Seuningen I.
Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells.
Gastric Cancer, 2013 May 24. [Epub ahead of print]. DOI 10.1007/s10120-013-0267-5. IF : 2,42

Skrypek N, Duchene B, Hebbar M, Leteurtre E, Van Seuningen I, Jonckheere N.
The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the concentrative nucleoside transporter family.
Oncogene, 2012 May 14. doi: 10.1038/onc.2012.179. [Epub ahead of print]. IF : 6,37.

Jonckheere N, Skrypek N, Merlin J, Dessein AF, Dumont P, Leteurtre E, Harris A, Desseyn JL, Susini C, Frénois F, Van Seuningen I.
The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.
PLoS ONE, 2012 7(2):e32232. IF : 4,09.

Jonckheere N, Vincent A, Franquet-Ansart H, Witte-Bouma J, Korteland-van Male A, Leteurtre E, Renes IB, Van Seuningen I.
GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.
BBA-Gene Regul Mech., 2012 Aug;1819(8):869-76. IF : 4,40.

Vincent DF, Gout J, Chuvin N, Arfi V, Pommier RM, Bertolino P, Jonckheere N, Ripoche D, Kaniewski B, Martel S, Langlois JB, Goddard Léon S, Colombe A, Janier M, Van Seuningen I, Losson R, Valcourt U, Treilleux I, Dubus P, Bardeesy N, Bartholin L.
γ Suppresses Murine pancreatic tumoral transformation by a Smad4-independent pathway.
Am J Pathol., 2012 Jun;180(6):2214-21. IF : 4,89.


Jonckheere N, Skrypek N, Frénois F, Van Seuningen I.
Membrane-bound mucin modular domains: from structure to function.
Biochimie, sous presse. IF : 3,02

Vincent A, Van Seuningen I.
On the epigenetic origin of cancer stem cells.
Biochim Biophys Acta -Rev Cancer. 2012 Apr 1;1826(1):83-88. IF : 9,37

Ledeen RW, Wu G, André S, Bleich D, Huet G, Kaltner H, Kopitz J, Gabius HJ.
Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1 [corrected].
Ann N Y Acad Sci. 2012 Apr;1253:206-21. doi: 10.1111/j.1749-6632.2012.06479.x. Review. Erratum in: Ann N Y Acad Sci. 2012 Jul;1258:191.

Merlin J, Stechly L, de Beaucé S, Monté D, Leteurtre E, Van Seuningen I, Huet G, Pigny P.
Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells.
Oncogene. 2011 Jun 2;30(22):2514-25]. IF : 7.40

Jonckheere N, Velghe A, Ducourouble MP, Copin MC, Renes IB, Van Seuningen I.
The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors.
FEBS J, 2011 Jan;278(2):282-94. IF : 3.13

Aissi-Ben Moussa S, Moussa A, Kourda N, Mezlini A, Abdelli N, Zerimech F, Najjar T, Jilani SB, Porchet N, Ayed FB, Manai M, Buisine MP.
Lynch syndrome in Tunisia: first description of clinical features and germline mutations.
Int J Colorectal Dis. 2011 Apr;26(4):455-67. IF : 2.64

Peignon G, Durand A, Cacheux W, Ayrault O, Terris B, Laurent-Puig P, Shroyer N F, Van Seuningen I, Honjo T, Perret C, Romagnolo B.
Complex interplay between {beta}-catenin signalling and Notch effectors in intestinal tumorigenesis.
Gut, 2011 Feb;60(2):166-76. IF : 10.61

Rebucci M, Peixoto P, Dewitte A, Wattez N, De Nuncques MA, Rezvoy N, Vautravers-Dewas C, Buisine MP, Guerin E, Peyrat JP, Lartigau E, Lansiaux A.
Mechanisms underlying resistance to cetuximab in the HNSCC cell line: Role of AKT inhibition in bypassing this resistance.
Int J Oncol. 2011 Jan;38(1):189-200. IF : 2.57

Dessein AF, Stechly L, Jonckheere N, Dumont P, Monté D, Leteurtre E, Truant S, Pruvot FR, Figeac M, Hebbar M, Lecellier CH, Lesuffleur T, Dessein R, Grard G, Dejonghe MJ, de Launoit Y, Furuichi Y, Prévost G, Porchet N, Gespach C, Huet G.
Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.
Cancer Res. 2010 Jun 1;70(11):4644-54. IF : 8.23

Rafa L, Dessein AF, Devisme L, Buob D, Truant S, Porchet N, Huet G, Buisine MP, Lesuffleur T.
REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells.
Int J Oncol. 2010 Mar;36(3):689-98. IF : 2.57

Jonckheere N, Van Seuningen I.
The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers.
Biochimie. 2010, 9, 1-11 (review). IF : 3.79

Jonckheere N, Skrypek N, Van Seuningen I.
Mucins and pancreatic cancer.
Cancers. 2010, 2, 1794-1812. (revue).


Aissi-Ben Moussa S, Moussa A, Lovecchio T, Kourda N, Najjar T, Ben Jilani S, El Gaaied A, Porchet N, Manai M, Buisine MP.
Identification and characterization of a novel MLH1 genomic rearrangement as the cause of HNPCC in a Tunisian family: evidence for a homologous Alu-mediated recombination.
Fam Cancer. 2009;8(2):119-26. IF : 2.14

Piessen G, Wacrenier A, Briez N, Triboulet JP, Van Seuningen I, Mariette C.
Clinical impact of MUC1 and MUC4 expression in Barrett-associated oesophageal adenocarcinoma.
J Clin Pathol. 2009 Dec;62(12):1144-6. IF : 2.47

Jonckheere N, Fauquette V, Stechly L, Saint-Laurent N, Aubert S, Susini C, Huet G, Porchet N, Van Seuningen I, Pigny P.
Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression.
Br J Cancer. 2009 Aug 18;101(4):637-44. IF : 4.83

Aubert S, Fauquette V, Hémon B, Lepoivre R, Briez N, Bernard D, Van Seuningen I, Leroy X, Perrais M.
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression.
Cancer Res. 2009 Jul 15;69(14):5707-15. IF : 8.23

Stechly L, Morelle W, Dessein AF, André S, Grard G, Trinel D, Dejonghe MJ, Leteurtre E, Drobecq H, Trugnan G, Gabius HJ, Huet G.
Galectin-4-regulated delivery of glycoproteins to the brush border membrane of enterocyte-like cells.
Traffic. 2009 Apr;10(4):438-50. IF : 5.28

Burger-van Paassen N, Vincent A, Puiman PJ, van der Sluis M, Bouma J, Boehm G, van Goudoever JB, van Seuningen I, Renes IB.
The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection.
Biochem J. 2009 May 13;420(2):211-9. IF : 5.01

Van Seuningen I, Vincent A.
Mucins: A new family of epigenetic biomarkers in epithelial cancers.
Expert Opin Med Diagnostics, (invited review), 2009, 3(4), 411-427. IF : 3.64

Vincent A, Van Seuningen I.
Epigenetics, stem cells and epithelial cell fate.
Differentiation. 2009 Sep-Oct;78(2-3):99-107. Epub 2009 Jul 24. Review. IF : 3.07

Morelle W, Stechly L, André S, Van Seuningen I, Porchet N, Gabius HJ, Michalski JC, Huet G.
Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking.
Biol Chem. 2009 Jul;390(7):529-44. (review). IF : 3.60

Yamaguchi K, Cekanova M, McEntee MF, Yoon JH, Fischer SM, Renes IB, Van Seuningen I, Baek SJ.
Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways.
Mol Cancer Ther. 2008 Sep;7(9):2779-87. IF : 5,22

Mejías-Luque R, Peiró S, Vincent A, Van Seuningen I, de Bolós C.
IL-6 induces MUC4 expression through gp130/STAT3 pathway in gastric cancer cell lines.
Biochim Biophys Acta. 2008 Oct;1783(10):1728-36. IF : 5,38

Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R.
Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.
J Pathol. 2008 Aug;215(4):411-20. IF : 6,32

Vincent A, Ducourouble MP, Van Seuningen I.
Epigenetic regulation of the human mucin gene MUC4 in epithelial cancer cell lines involves both DNA methylation and histone modifications mediated by DNA methyltransferases and histone deacetylases.
FASEB J. 2008 Aug;22(8):3035-45. IF : 5,71

Van der Sluis M, Bouma J, Vincent A, Velcich A, Carraway KL, Büller HA, Einerhand AW, van Goudoever JB, Van Seuningen I, Renes IB.
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: mucin 2-interleukin 10-deficient mice.
Lab Invest. 2008 Jun;88(6):634-42. IF : 3,64

Mariette C, Piessen G, Leteurtre E, Hémon B, Triboulet JP, Van Seuningen I.
Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase.
Surgery. 2008 Jan;143(1):58-71. IF : 3,10

Jonckheere N, Van Seuningen I.
The membrane-bound mucins: How large O-glycoproteins play key roles in epithelial cancers and hold promise as biological tools for gene-based and immunotherapies.
Crit Rev Oncog. 2008, 14(2-3), 177-196.


Van Seuningen I.
Editeur-en-chef du livre « The epithelial mucins. Structure/function. Roles in cancer and inflammatory diseases”.
Editeur: Isabelle Van Seuningen, Research SignPost, Kerala, India. 2008

Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, Van Seuningen I.
The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells.
J Biol Chem. 2007 Aug 3;282(31):22638-50. IF : 4,77

Vincent A, Perrais M, Desseyn JL, Aubert JP, Pigny P, Van Seuningen I.
Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.
Oncogene. 2007 Oct 4;26(45):6566-6576. IF : 6,37

Fauquette V, Aubert S, Groux-Degroote S, Hemon B, Porchet N, Van Seuningen I, Pigny P.
Transcription Factor AP-2{alpha} Represses Both the Mucin MUC4 Expression and Pancreatic Cancer Cell Proliferation.
Carcinogenesis. 2007 Nov;28(11):2305-12. IF : 5,70

Piessen G, Jonckheere N, Vincent A, Hemon B, Ducourouble MP, Copin MC, Mariette C, Van Seuningen I.
Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha.
Biochem J. 2007 Feb 15;402(1):81-91. IF : 4,89