Publications

 

Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, Loyens A, Dufour N, Aurégan G, Winderickx J, Hantraye P, Déglon N, Buée L, Colin M.
Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain.
Mol Ther. 2013 Apr 23. doi: 10.1038/mt.2013.66.


Hernández-Hernández O, Guiraud-Dogan C, Sicot G, Huguet A, Luilier S, Steidl E, Saenger S, Marciniak E, Obriot H, Chevarin C, Nicole A, Revillod L, Charizanis K, Lee KY, Suzuki Y, Kimura T, Matsuura T, Cisneros B, Swanson MS, Trovero F, Buisson B, Bizot JC, Hamon M, Humez S, Bassez G, Metzger F, Buée L, Munnich A, Sergeant N, Gourdon G, Gomes-Pereira M.
Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.

Brain. 2013 Mar;136(Pt 3):957-70. doi: 10.1093/brain/aws367.


Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV, Geller F, Sottejeau Y, Harold D, Dourlen P, Grenier-Boley B, Kamatani Y, Delepine B, Demiautte F, Zelenika D, Zommer N, Hamdane M, Bellenguez C, Dartigues JF, Hauw JJ, Letronne F, Ayral AM, Sleegers K, Schellens A, Broeck LV, Engelborghs S, De Deyn PP, Vandenberghe R, O’Donovan M, Owen M, Epelbaum J, Mercken M, Karran E, Bantscheff M, Drewes G, Joberty G, Campion D, Octave JN, Berr C, Lathrop M, Callaerts P, Mann D, Williams J, Buée L, Dewachter I, Van Broeckhoven C, Amouyel P, Moechars D, Dermaut B, Lambert JC.
Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.
Mol Psychiatry. 2013 Feb 12. doi: 10.1038/mp.2013.1.


Leboucher A, Laurent C, Fernandez-Gomez FJ, Burnouf S, Troquier L, Eddarkaoui S, Demeyer D, Caillierez R, Zommer N, Vallez E, Bantubungi K, Breton C, Pigny P, Buée-Scherrer V, Staels B, Hamdane M, Tailleux A, Buée L, Blum D.
Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice.
Diabetes. 2013 May;62(5):1681-8. doi: 10.2337/db12-0866.


Gabelle A, Dumurgier J, Vercruysse O, Paquet C, Bombois S, Laplanche JL, Peoc’h K, Schraen S, Buée L, Pasquier F, Hugon J, Touchon J, Lehmann S.
Impact of the 2008-2012 French Alzheimer Plan on the use of cerebrospinal fluid biomarkers in research memory center: the PLM Study.
J Alzheimers Dis. 2013 Jan 1;34(1):297-305. doi: 10.3233/JAD-121549.


Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, Fernandez-Gomez FJ, Troquier L, Eddarkaoui S, Grosjean ME, Demeyer D, Muhr-Tailleux A, Buisson A, Sergeant N, Hamdane M, Humez S, Popoli P, Buée L, Blum D. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.
Aging Cell. 2013 Feb;12(1):11-23. doi: 10.1111/acel.12018.


Bombois S, Duhamel A, Salleron J, Deramecourt V, Mackowiak MA, Deken V, Sergeant N, Pasquier F, Buée L, Sablonniére B, Schraen-Maschke S.
A New Decision Tree Combining Abeta 1-42 and p-Tau Levels in Alzheimer’s Diagnosis.
Curr Alzheimer Res. 2013 May 1;10(4):357-64.


Gabelle A, Richard F, Gutierrez LA, Schraen S, Delva F, Rouaud O, Buée L, Dartigues JF, Touchon J, Lambert JC, Berr C.
Plasma amyloid-β levels and prognosis in incident dementia cases of the 3-City Study.
J Alzheimers Dis. 2013;33(2):381-91. doi: 10.3233/JAD-2012-121147.


Dorval V, Smith PY, Delay C, Calvo E, Planel E, Zommer N, Buée L, Hébert SS.
Gene network and pathway analysis of mice with conditional ablation of Dicer in post-mitotic neurons.
PLoS One. 2012;7(8):e44060. doi: 10.1371/journal.pone.0044060


Ando K, Dourlen P, Sambo AV, Bretteville A, Bélarbi K, Vingtdeux V, Eddarkaoui S, Drobecq H, Ghestem A, Bégard S, Demey-Thomas E, Melnyk P, Smet C, Lippens G, Maurage CA, Caillet-Boudin ML, Verdier Y, Vinh J, Landrieu I, Galas MC, Blum D, Hamdane M, Sergeant N, Buée L.
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker.
Neurobiol Aging. 2013 Mar;34(3):757-69. doi: 10.1016/j.neurobiolaging.2012.08.004. Epub 2012 Aug 25.


Vingtdeux V, Sergeant N, Buée L.
Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer’s disease.

Front Physiol. 2012;3:229. doi: 10.3389/fphys.2012.00229.


Deramecourt V, Lebert F, Maurage CA, Fernandez-Gomez FJ, Dujardin S, Colin M, Sergeant N, Buée-Scherrer V, Clot F, Ber IL, Brice A, Pasquier F, Buée L.
Clinical, neuropathological, and biochemical characterization of the novel tau mutation P332S.
J Alzheimers Dis. 2012;31(4):741-9. doi: 10.3233/JAD-2012-120160.


Brouillette J, Caillierez R, Zommer N, Alves-Pires C, Benilova I, Blum D, De Strooper B, Buée L.
Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.
J Neurosci. 2012 Jun 6;32(23):7852-61. doi: 10.1523/JNEUROSCI.5901-11.2012.


Lécolle K, Bégard S, Caillierez R, Demeyer D, Grellier E, Loyens A, Csaba Z, Beauvillain JC, D’Halluin JC, Baroncini M, Lejeune JP, Sharif A, Prévot V, Dournaud P, Buée L, Colin M.
Sstr2A: a relevant target for the delivery of genes into human glioblastoma cells using fiber-modified adenoviral vectors.
Gene Ther. 2013 Mar;20(3):283-97. doi: 10.1038/gt.2012.39.


Le Freche H, Brouillette J, Fernandez-Gomez FJ, Patin P, Caillierez R, Zommer N, Sergeant N, Buée-Scherrer V, Lebuffe G, Blum D, Buée L.
Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment.
Anesthesiology. 2012 Apr;116(4):779-87. doi: 10.1097/ALN.0b013e31824be8c7.


Troquier L, Caillierez R, Burnouf S, Fernandez-Gomez FJ, Grosjean ME, Zommer N, Sergeant N, Schraen-Maschke S, Blum D, Buee L.
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Curr Alzheimer Res. 2012 May;9(4):397-405.


Burnouf S, Belarbi K, Troquier L, Derisbourg M, Demeyer D, Leboucher A, Laurent C, Hamdane M, Buee L, Blum D.
Hippocampal BDNF expression in a tau transgenic mouse model.
Curr Alzheimer Res. 2012 May;9(4):406-10.


Féart C, Helmer C, Fleury H, Béjot Y, Ritchie K, Amouyel P, Schraen-Maschke S, Buée L, Lambert JC, Letenneur L, Dartigues JF.
Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels.
PLoS One. 2011;6(12):e29480. doi: 10.1371/journal.pone.0029480.


Smith PY, Delay C, Girard J, Papon MA, Planel E, Sergeant N, Buée L, Hébert SS.
MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy.
Hum Mol Genet. 2011 Oct 15;20(20):4016-24. doi: 10.1093/hmg/ddr330.


Deramecourt V, Maurage CA, Sergeant N, Buée-Scherrer V, Buée L, Defebvre L.
An 88-year old woman with long-lasting parkinsonism.
Brain Pathol. 2011 Jul;21(4):465-8. doi: 10.1111/j.1750-3639.2011.00496.x.


Belarbi K, Burnouf S, Fernandez-Gomez FJ, Desmercières J, Troquier L, Brouillette J, Tsambou L, Grosjean ME, Caillierez R, Demeyer D, Hamdane M, Schindowski K, Blum D, Buée L.
Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology?
Curr Alzheimer Res. 2011 Sep;8(6):633-8.


Belarbi K, Burnouf S, Fernandez-Gomez FJ, Laurent C, Lestavel S, Figeac M, Sultan A, Troquier L, Leboucher A, Caillierez R, Grosjean ME, Demeyer D, Obriot H, Brion I, Barbot B, Galas MC, Staels B, Humez S, Sergeant N, Schraen-Maschke S, Muhr-Tailleux A, Hamdane M, Buée L, Blum D.
Beneficial effects of exercise in a transgenic mouse model of Alzheimer’s disease-like Tau pathology.
Neurobiol Dis. 2011 Aug;43(2):486-94. doi: 10.1016/j.nbd.2011.04.022.


Lambert JC, Dallongeville J, Ellis KA, Schraen-Maschke S, Lui J, Laws S, Dumont J, Richard F, Cottel D, Berr C, Ames D, Masters CL, Rowe CC, Szoeke C, Tzourio C, Dartigues JF, Buée L, Martins R, Amouyel P.
Association of plasma Aß peptides with blood pressure in the elderly.
PLoS One. 2011 Apr 15;6(4):e18536. doi: 10.1371/journal.pone.0018536.


Tran H, Gourrier N, Lemercier-Neuillet C, Dhaenens CM, Vautrin A, Fernandez-Gomez FJ, Arandel L, Carpentier C, Obriot H, Eddarkaoui S, Delattre L, Van Brussels E, Holt I, Morris GE, Sablonnière B, Buée L, Charlet-Berguerand N, Schraen-Maschke S, Furling D, Behm-Ansmant I, Branlant C, Caillet-Boudin ML, Sergeant N.
Analysis of exonic regions involved in nuclear localization, splicing activity, and dimerization of Muscleblind-like-1 isoforms.
J Biol Chem. 2011 May 6;286(18):16435-46. doi: 10.1074/jbc.M110.194928.


Dhaenens CM, Tran H, Frandemiche ML, Carpentier C, Schraen-Maschke S, Sistiaga A, Goicoechea M, Eddarkaoui S, Van Brussels E, Obriot H, Labudeck A, Gevaert MH, Fernandez-Gomez F, Charlet-Berguerand N, Deramecourt V, Maurage CA, Buée L, de Munain AL, Sablonnière B, Caillet-Boudin ML, Sergeant N.
Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing.
Biochim Biophys Acta. 2011 Jul;1812(7):732-42. doi: 10.1016/j.bbadis.2011.03.010.


Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean ME, Humez S, Balschun D, Blum D, Buée L, D’Hooge R.
Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.
Neurobiol Learn Mem. 2011 Mar;95(3):296-304. doi: 10.1016/j.nlm.2010.12.005.


Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, Mansuroglu Z, Marzin D, Sergeant N, Humez S, Colin M, Bonnefoy E, Buée L, Galas MC.
Nuclear tau, a key player in neuronal DNA protection.
J Biol Chem. 2011 Feb 11;286(6):4566-75. doi: 10.1074/jbc.M110.199976.


Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buée L, Galas MC, Winderickx J.
Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner.
PLoS One. 2010 Oct 27;5(10):e13700. doi: 10.1371/journal.pone.0013700.


Hébert SS, Papadopoulou AS, Smith P, Galas MC, Planel E, Silahtaroglu AN, Sergeant N, Buée L, De Strooper B.
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration.
Hum Mol Genet. 2010 Oct 15;19(20):3959-69. doi: 10.1093/hmg/ddq311.


Leroy K, Ando K, Héraud C, Yilmaz Z, Authelet M, Boeynaems JM, Buée L, De Decker R, Brion JP.
Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology.
J Alzheimers Dis. 2010;19(2):705-19. doi: 10.3233/JAD-2010-1276.


Petzold A, Chapman MD, Schraen S, Verwey NA, Pasquier F, Bombois S, Brettschneider J, Fox NC, von Arnim CA, Teunissen C, Pijnenburg Y, Riepe MW, Otto M, Tumani H, Scheltens P, Buee L, Rossor MN.
An unbiased, staged, multicentre, validation strategy for Alzheimer’s disease CSF tau levels.
Exp Neurol. 2010 Jun;223(2):432-8. doi: 10.1016/j.expneurol.2009.11.010.


Deramecourt V, Lebert F, Debachy B, Mackowiak-Cordoliani MA, Bombois S, Kerdraon O, Buée L, Maurage CA, Pasquier F.
Prediction of pathology in primary progressive language and speech disorders.
Neurology. 2010 Jan 5;74(1):42-9. doi: 10.1212/WNL.0b013e3181c7198e.


Lambert JC, Schraen-Maschke S, Richard F, Fievet N, Rouaud O, Berr C, Dartigues JF, Tzourio C, Alpérovitch A, Buée L, Amouyel P.
Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study.
Neurology. 2009 Sep 15;73(11):847-53. doi: 10.1212/WNL.0b013e3181b78448.


Dhaenens CM, Burnouf S, Simonin C, Van Brussel E, Duhamel A, Defebvre L, Duru C, Vuillaume I, Cazeneuve C, Charles P, Maison P, Debruxelles S, Verny C, Gervais H, Azulay JP, Tranchant C, Bachoud-Levi AC, Dürr A, Buée L, Krystkowiak P, Sablonnière B, Blum D; Huntington French Speaking Network.
A genetic variation in the ADORA2A gene modifies age at onset in Huntington’s disease.
Neurobiol Dis. 2009 Sep;35(3):474-6. doi: 10.1016/j.nbd.2009.06.009.


Belarbi K, Schindowski K, Burnouf S, Caillierez R, Grosjean ME, Demeyer D, Hamdane M, Sergeant N, Blum D, Buée L.
Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer’s disease.
Curr Alzheimer Res. 2009 Apr;6(2):152-7


Bretteville A, Ando K, Ghestem A, Loyens A, Bégard S, Beauvillain JC, Sergeant N, Hamdane M, Buée L.
Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes.
PLoS One. 2009;4(3):e4843. doi: 10.1371/journal.pone.0004843.


Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, DeKosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC.
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer’s disease.
Mol Psychiatry. 2009 Nov;14(11):1004-16. doi: 10.1038/mp.2009.10


Ghanem D, Tran H, Dhaenens CM, Schraen-Maschke S, Sablonnière B, Buée L, Sergeant N, Caillet-Boudin ML.
Altered splicing of Tau in DM1 is different from the foetal splicing process.
FEBS Lett. 2009 Feb 18;583(4):675-9. doi: 10.1016/j.febslet.2008.12.065.


Dhaenens CM, Schraen-Maschke S, Tran H, Vingtdeux V, Ghanem D, Leroy O, Delplanque J, Vanbrussel E, Delacourte A, Vermersch P, Maurage CA, Gruffat H, Sergeant A, Mahadevan MS, Ishiura S, Buée L, Cooper TA, Caillet-Boudin ML, Charlet-Berguerand N, Sablonnière B, Sergeant N.
Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats.
Exp Neurol. 2008 Apr;210(2):467-78. doi: 10.1016/j.expneurol.2007.11.020


Bensemain F, Hot D, Ferreira S, Dumont J, Bombois S, Maurage CA, Huot L, Hermant X, Levillain E, Hubans C, Hansmannel F, Chapuis J, Hauw JJ, Schraen S, Lemoine Y, Buée L, Berr C, Mann D, Pasquier F, Amouyel P, Lambert JC.
Evidence for induction of the ornithine transcarbamylase expression in Alzheimer’s disease.
Mol Psychiatry. 2009 Jan;14(1):106-16.