Scientific project

Neurodegenerative disorders and neuronal death Luc Buée

The work of our team is a major theme of research on the campus of the County Hospital and the University of Lille (CHU-Lille). It results from a long-time and fruitful collaboration among clinician neurologists, neuro-pathologists and research scientists in biochemistry and molecular and cell biology. It focuses on the physiopathology of neuro-degenerative disorders going from the gene to the clinic and from basic research to biomedical application. Our team is interested in molecular mechanisms of neuro-degenerative disorders. Our main contribution has been on the characterization of neuro-degenerative disorders with dysfunction in tau metabolism (expression, splicing,etc…). We also demonstrated that Tau proteins are biomarkers of these disorders and correlated to neuronal death.

Our current research should lead to new diagnostic and therapeutic strategies of Alzheimer’s disease and related disorders. To the level of the etiopathogenesis of Alzheimer’s disease, the understanding of the relationships between amyloid pathology and tau pathology is our main goal. Any molecular actors potentially involved in one of these pathways will be evaluated in our experimental “humanized” models, as well as the related pharmacological aspects. Furthermore, any factors involved in neuronal death is also of interest and thus, other neurodegenerative disorders will be analyzed at the genomics, proteomics, cell and physiological levels.

Our team unified around with this research project has the will, the capacity and the ambition to play a decisive role in the understanding of neurodegenerative disorders.